Association between uric acid to high-density lipoprotein cholesterol ratio and diabetic kidney disease in US adults
American Diabetes Association. Microvascular complications and foot care: standards of medical care in diabetes-2020. Diabetes Care. 43, 135–151 (2020).
Google Scholar
Thomas, M. C. et al. Diabetic kidney disease. Nat. Rev. Dis. Primers. 1, 15018 (2015).
Google Scholar
Sensen Wu, H. et al. Association between hyperuricemia and diabetic nephropathy: insights from the National health and nutrition examination survey 2007–2016 and Mendelian randomization analysis. Int. Urol. Nephrol. 56, 3351–3359 (2024).
Google Scholar
Gong, L. et al. High concentrations of triglycerides are associated with diabetic kidney disease in new-onset type 2 diabetes in china: findings from the China cardiometabolic disease and Cancer cohort (4 C) study. Diabetes Obes. Metab. 23, 2551–2560 (2021).
Google Scholar
Pontremoli, R., Fioretto, P. & AMD-Annals Study Group. Plasma triglycerides and HDL-C levels predict the development of diabetic kidney disease in subjects with type 2 diabetes: the AMD annals initiative. Diabetes Care. 39, 2278–2287 (2016).
Google Scholar
Gao, R. H. et al. Serum lipoprotein(a) and High-Density lipoprotein cholesterol associate with diabetic nephropathy: evidence from machine learning perspectives. Diabetes Metab. Syndr. Obes. 16, 1847–1858 (2023).
Google Scholar
Kurtkulagi, O. et al. Hashimoto’s thyroiditis is associated with elevated serum uric acid to high density lipoprotein-cholesterol ratio. Rom J. Intern. Med. 59, 403–408 (2021).
Google Scholar
Kosekli, M. A. et al. The association between serum uric acid to high density lipoprotein-cholesterol ratio and non-alcoholic fatty liver disease: the Abund study. Rev. Assoc. Med. Bras. 67, 549–554 (1992).
Google Scholar
Yazdi, F. et al. Investigating the relationship between serum uric acid to high-density lipoprotein ratio and metabolic syndrome. Endocrinol. Diabetes Metab. 5, e00311 (2022).
Google Scholar
Aktas, G. et al. Uric acid to HDL cholesterol ratio is a strong predictor of diabetic control in men with type 2 diabetes mellitus. Aging Male. 23, 1098–1102 (2020).
Google Scholar
Kocak, M. Z. et al. Serum uric acid to HDL-cholesterol ratio is a strong predictor of metabolic syndrome in type 2 diabetes mellitus. Rev. Assoc. Med. Bras. 65, 9–15 (2019).
Google Scholar
Sun, H. P. et al. Serum uric acid to highdensity lipoprotein cholesterol ratio is associated with visceral fat in patients with type 2 diabetes. Diabetes Metab. Syndr. Obes. 16, 959–967 (2023).
Google Scholar
Cheng, Y. et al. Association between serum uric acid/HDL-cholesterol ratio and chronic kidney disease: a cross-sectional study based on a health check-up population. BMJ Open. 12, e066243 (2022).
Google Scholar
Liu, P. et al. Association between cumulative uric acid to high-density lipoprotein cholesterol ratio and the incidence and progression of chronic kidney disease. Front. Endocrinol. (Lausanne). 14, 1269580 (2023).
Google Scholar
Rongfeng Han, L. et al. Serum uric acid is a better Indicator of kidney impairment than serum uric acid-to-Creatinine ratio and serum uric acid-to-High-Density lipoprotein ratio: A Cross-Sectional study of type 2 diabetes mellitus patients. Diabetes Metab. Syndr. Obes. 16, 2695–2703 (2023).
Google Scholar
Zou, X. et al. Novel subgroups of patients with adult-onset diabetes in Chinese and US populations. Lancet Diabetes Endocrinol. 7 (1), 9–11 (2019).
Google Scholar
Levey, A. S. et al. A new equation to estimate glomerular filtration rate. Ann. Intern. Med. 150, 604–612 (2009).
Google Scholar
Kidney Disease. Improving global outcomes (KDIGO) glomerular diseases work group. KDIGO. Clinical practice guideline for the management of glomerular diseases. Kidney Int. 100, S1–S276 (2021).
Cao, B. et al. The association between stress-induced hyperglycemia ratio and cardiovascular events as well as all-cause mortality in patients with chronic kidney disease and diabetic nephropathy. Cardiovasc. Diabetol. 24, 55 (2025).
Google Scholar
Minhas, A. M. K. et al. Family income and cardiovascular disease risk in American adults. Sci. Rep. 13, 279 (2023).
Google Scholar
WheltonPK et al. 2017 acc/aha/aapa/abc/acpm/ags/apha/ash/aspc/nma/pcna guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American college of cardiology/american heart association task force on clinical practice guidelines. J. Am. Coll. Cardiol. 71, e127–e248 (2018).
Google Scholar
n-3 PUFA poor seafood consumption is associated with higher risk of gout, whereas n-3 PUFA rich seafood is not: NHANES 2007–2016. Front. Nutr. 10, 1075877 (2023).
Google Scholar
MacGregor, K. A., Gallagher, I. J. & Moran, C. N. Relationship between insulin sensitivity and menstrual cycle is modified by BMI, fitness, and physical activity in NHANES.J. Clin. Endocrinol. Metab. 106, 2979–2990 (2021).
Google Scholar
Yao, J. et al. Combined influence of nutritional and inflammatory status and depressive symptoms on mortality among US cancer survivors: findings from the NHANES. Brain Behav. Immun. 115, 109–117 (2024).
Google Scholar
WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 363, 157–163 (2004).
Google Scholar
Tuttle, K. R. et al. Molecular mechanisms and therapeutic targets for diabetic kidney disease. Kidney Int. 102, 248–260 (2022).
Google Scholar
Pérez-Morales, R. E. et al. Inflamm. Diabet. Kidney Disease Nephron 143 12–16. (2019).
Alicic, R. Z., Johnson, E. J. & Tuttle, K. R. Inflammatory mechanisms as new biomarkers and therapeutic targets for diabetic kidney disease. Adv. Chronic Kidney Dis. 25, 181–191 (2018).
Google Scholar
Niewczas, M. A. et al. A signature of Circulating inflammatory proteins and development of end-stage renal disease in diabetes. Nat. Med. 25, 805–813 (2019).
Google Scholar
Zhang, R. et al. Increased neutrophil count is associated with the development of chronic kidney disease in patients with diabetes. J. Diabetes. 14, 442–454 (2022).
Google Scholar
Chung, F. M. et al. Peripheral total and differential leukocyte count in diabetic nephropathy: the relationship of plasma leptin to leukocytosis. Diabetes Care. 28, 1710–1717 (2005).
Google Scholar
Li, X. et al. Association between neutrophil-to-lymphocyte ratio and diabetic kidney disease in type 2 diabetes mellitus patients: a cross-sectional study. Front. Endocrinol. (Lausanne). 14, 1285509 (2024 ).
Google Scholar
Guo, W. et al. Systemic immune-inflammation index is associated with diabetic kidney disease in type 2 diabetes mellitus patients: evidence from NHANES 2011–2018.Front. Endocrinol. (Lausanne). 13:1071465. (2022).
Qiao Jin, Eric, S. H. et al. Circulating metabolomic markers linking diabetic kidney disease and incident cardiovascular disease in type 2 diabetes: analyses from the Hong. Kong Diabetes Biobank Diabetologia. 67, 837–849 (2024).
Xuan, Y. et al. Association between uric acid to HDL cholesterol ratio and diabetic complications in men and postmenopausal women. Diabetes Metab. Syndr. Obes. 16, 167–177 (2023).
Google Scholar
Aktas, G. et al. Is serum uric acid-to-HDL cholesterol ratio elevation associated with diabetic kidney injury?Postgrad. Med 135, 519–523 (2023).
Google Scholar
Kang DH, Nakagawa T, Feng L, et al. A role for uric acid in the progression of renal disease.J. Am. Soc. Nephrol. 13 2888–2897.
Komers, R. et al. Effects of Xanthine oxidase Inhibition with febuxostat on the development of nephropathy in experimental type 2 diabetes. Br. J. Pharmacol. 173, 2573–2588 (2016).
Google Scholar
Gaubert, M. et al. Hyperuricemia and hypertension, coronary artery disease, kidney disease: from concept to practice. Int. J. Mol. Sci. 21, 4066 (2020).
Google Scholar
Izquierdo-Lahuerta, A., Martínez-García, C. & Medina-Gómez, G. Lipotoxicity as a trigger factor of renal disease. J. Nephrol. 29, 603–610 (2016).
Google Scholar
Kimura, T. et al. High-density lipoprotein stimulates endothelial cell migration and survival through sphingosine 1-phosphate and its receptors. Arterioscler. Thromb. Vasc Biol. 23, 1283–1288 (2003).
Google Scholar
Scanu, A. et al. High-density lipoproteins inhibit urate crystal-induced inflammation in mice. Ann. Rheum. Dis. 74, 587–594 (2015).
Google Scholar
Zhou, X. & Xu, J. Association between serum uric acid-to‐high‐density lipoprotein cholesterol ratio and insulin resistance in an American population: A population‐based analysis. J. Diabetes Investig. 15, 762–771 (2024).
Google Scholar
Kolahi Ahari R、Mansoori A、Sahranavard, T. et al. Serum uric acid to high-density lipoprotein ratio as a novel indicator of inflammation is correlated with the presence and severity of metabolic syndrome: A large‐scale study. Endocrinol. Diabetes Metab. 6, e446 (2023).
Google Scholar
Radcliffe NJ、Seah JM、Clarke, M. et al. Clinical predictive factors in diabetic kidney disease progression. J. Diabetes Investig. 8, 6–18 (2017).
Google Scholar
Wang, X., Bonventre, J. V. & Parrish, A. R. The aging kidney: increased susceptibility to nephrotoxicity. Int. J. Mol. Sci. 15, 15358–15376 (2014).
Google Scholar
Del Giudice, A. & Aucella, F. Acute renal failure in the elderly: epidemiology and clinical features. J. Nephrol. 25, S48–57 (2012).
Google Scholar
Choudhury, D., Tuncel, M. & Levi, M. Disorders of lipid metabolism and chronic kidney disease in the elderly. Semin Nephrol. 29, 610–620 (2009).
Google Scholar
Tseng, W. C. et al. Hyperuricemia predicts an early decline in renal function among older people: A Community-Based cohort study. Sci. Rep. 9, 980 (2019).
Google Scholar
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